How many people will be in this study?
We are looking for 16 healthy volunteers and 16 individuals with obesity and prediabetes to complete this study. We are currently recruiting healthy volunteers only.
Where do I go for the study?
This study takes place at both Johns Hopkins Bayview Medical Center and the NIH Clinical Center. First, you will come to the Johns Hopkins Bayview campus for the screening visit and the overnight DLMO visit. Next, you will come to the NIH Clinical Center for 2 overnight metabolic visits. Directions for both locations can be found on this page.
How long do I have to stay in the research unit and what can I do there?
•For the screening visit (Johns Hopkins), you will be in the research unit for approximately 3-4 hours.
•For the overnight DLMO visit (Johns Hopkins), you will be in the research unit starting from 12pm on day 1 (lunch provided) until the next morning (day 2), anytime between 8am-11am (breakfast provided). During this overnight visit, you can use your phone and watch TV but cannot use your computer.
•For the overnight metabolic visits (NIH), you will be in the research unit starting around 4pm on day 1 (dinner provided), stay over 2 consecutive nights (all 3 meals provided), and leave on day 3 after breakfast. During these metabolic visits, you will be in a specialized metabolic room where you can use your phone, computer, and watch TV.
Will transportation be provided?
Financial compensation of $100 will be provided for transportation as part of the study, but you must arrange your own transportation to both Johns Hopkins Bayview (located in Baltimore, MD) and National Institutes of Health (located in Bethesda, MD) campuses.
What kind of food will I be served?
In order to study your metabolic response and how you use energy, it is important that we control the nutrients you get from your diet and make sure that all study participants get similar amounts of these nutrients. You will meet with our nutrition staff during the screening procedures to set up your menu before the study begins. The menus include common foods like sandwiches, eggs, beef, seafood, and chicken. We are able to accommodate dietary restrictions including vegetarian and gluten-free diets. Please inform the study dietitian or technician during your screening visit if you are unable and unwilling to eat any of the foods on the study menu.
What are the risks of the study?
•Blood tests: Putting in IV’s and drawing blood may cause discomfort, bleeding or bruising where the needle enters the body. There is a small risk of infection.
•DEXA Scan: This test includes exposure to radiation from x-rays or gamma rays. This is similar to a chest X-ray but uses less than 10% of the radiation.
•Isotope ingestion: The isotope you will receive is a naturally occurring compound and is not radioactive.
•Metabolic room: There may be inconveniences and discomfort that can reasonably be expected as a result of spending an extended period of time in the live-in metabolic room. You can communicate any concerns or discomfort through the intercom and see the nursing staff through a window. Members of the nursing staff will be present outside the room for the entire duration of the study. You can leave the chamber if unable to tolerate.
How does payment for the study work?
You will be paid up to $1400 for completing all parts of this study. In addition, you will receive an additional $100 at the end of the study if you come to all your visits without schedule changes. You will also receive parking reimbursement for both Johns Hopkins and NIH.
Can I get the results of the tests involved in this study?
Dinner Time for Obesity and Prediabetes 